|
|
|
|
|
Picture credit: Marieke de Lorijn
Axonal Signalling Group,
Netherlands Institute for Neuroscience,
Royal Academy of Arts and Sciences,
Meibergdreef 47,
1105 BA Amsterdam,
The Netherlands
Date & place of Birth September 1985 (New Delhi, INDIA)
Education and Experience
2022-present: - ZonMw Dementia research fellow at Netherlands Institute for Neuroscience.
2017-2022:- Postdoc researcher at the Axonal Signalling group, under the supervision of Prof. Dr. Maarten Kole. Netherlands Institute for Neuroscience. The Netherlands
2018-2020:- Honorarium editor of Amsterdam Science Magazine, Science Park, Amsterdam
2011-2017: - PhD Neuroscience, Department of Child Neurology, VUmc & Department of Integrative Neurophysiology, CNCR, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands.
Supervisors: Prof. Dr. Marjo van der Knaap and Prof. Dr. Huib Mansvelder.
2009-2010: - Masters of Science in Pharmacology, University of Oxford, UK.
Grade: - Distinction in oral presentation, extended essay and qualifying exam.
Dissertation title: nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons.
Supervisor: Prof. Dr. Karri Lamsa.
2005-2009: - Bachelor of Pharmacy, Guru Gobind Singh IP Univ, New Delhi, India.
Registered Pharmacist, Indian Pharmacy Council, New Delhi, India.
Grade: - 81.54%. First with distinction.
Project title: Characterization of anti-epileptic drugs in epileptic mice model.
Supervisor: Prof. Dr. Uma Tekur, Department of Pharmacology, Maulana Azad Medical College. New Delhi, India.
Proven skills and strengths
Awards
2016 Mahatma Gandhi Pravasi Samman (civilian award), Global India Summit 2016 from NRI society at the House of Lords, London, UK.
2016 ICEN Travel award to FENS meeting- Copenhagen, Denmark.
2015 Best presentation award, Annual Neuroscience Campus Amsterdam, The Netherlands.
2015 NIH-Chair travel funds for Gordon Conference and Seminars, California, USA.
2015 FameLab heat Nijmegen, British Council Netherlands.
2014 Outstanding Scientific Contribution award, International Astrocyte School, Italy.
2014 Best presentation award, Amsterdam Children Symposium, Amsterdam, The Netherlands.
2013 Best presentation award, Annual Neuroscience Campus Amsterdam, The Netherlands.
2009 Oxford-Cambridge Indian Society nomination for Masters study at Oxford University.
2009 GATE 2009 (Graduate Aptitude Test in Engineering); exam-based scholarship conducted by 7 Indian Institute of Technology, MHRD, Govt. of India.
2002 Outstanding performance at National Science Exhibition, National Center for Education and Training (NCERT), Govt. of India.
2001 Outstanding performance at State Science Exhibition, Directorate of Education, Govt. of Delhi.
Teaching experience
2015 EEG radio-telemtry, FENS summer school (The Netherlands).
2014 Supervision of a neuroscience master student (University of Amsterdam, The Netherlands)
2013 Supervision of a neuroscience master student (University of Amsterdam, The Netherlands)
2012 Practical training for electrophysiology in Neuroscience course (Master program in neuroscience, VU university, Amsterdam, The Netherlands)
2010 Practical and surgical training at Medical Science Training Center (Bachelor program in Medicine & Physiology, University of Oxford, The United Kingdom
2009 Class room teaching of physics and physiology for International Baccalaureate students (St Hildas College, SAES, Oxford, The United Kingdom)
Publication
Mice with Megalencephalic Leukoencephalopathy with Cysts: A developmental angle.
Dubey M*, Bugiani M*, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weeing JR, M Heine V, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS. (Annals of Neurology; 2015). Image from the study selected for front page of the journal. (*Equal contribution)
Megalencephalic Leukoencephalopathy with Cysts; the Glialcam-null mouse model. Bugiani M*, Dubey M*, M. Breur, N.L. Postma, M.P. Dekker, T. ter Braak, U. Boschert, T.E.M. Abbink, H.D. Mansvelder, R. Min, J.R.T. van Weering, M.S. van der Knaap (Annals of Clinical and Translational Neurology; 2017) (*Equal contribution)
Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC.
Dubey M*, Brouwers E*, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min (Annals of Neurology; 2018) (*Equal contribution)
Seizures and cognitive deficits in STXBP1-encephalopathy are explained by impaired protein stability, haploinsufficiency and excitation-inhibition imbalance, especially in neocortex. Kovačević J*, Maroteaux G*, Schut D*, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse L. N, Sullivan P, Schoch-McGovern S, Toonen R F., Stiedl O and Verhage Matthijs. (Brain; 2018) (*Equal contribution)
Continue Education
2014 4th International Astrocyte School (Bertinoro, Italy)
2014 “Write it Right” from NWO, The Netherlands.
2011-14 Graduate School Neurosciences Amsterdam (modules attended)
2011 Handling of experimental animals (Dutch certificate article 9)
2009 Home office, UK personal license module 1-4 for rat, mouse and guniea pig.
Additional activities and memberships
2015- 2016 Honorarium editor of Amsterdam Science Magazine, Science Park, Amsterdam
2011- Present Member of the Federation of European Neuroscience Society (FENS).
2011- Present Member of the Dutch Neuro-federation.
2010- Present Member of the Oxford-Cambridge Indian Society, New Delhi, India
2009- Present Lifetime member of the Indian Pharmacy Graduate Association(IPGA), India.
2012- 2014 Member of the organizing committee of the annual meeting for PhD students of the Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience (ONWAR).
2013- 2014 Founder member and President of the VU-University Indian Society,Amsterdam, The Netherlands.
2011-2014 Member of the organizing committee of the monthly meetings for PhD students of the Center for Neurogenomics & Cognitive Research (CNCR), The Netherlands.
2009-2010 Worked as ancient book coder at Oxford University Bodleian Library, University of Oxford, The United Kingdom.
2009-2010 Member of the Oxford Indian Society, University of Oxford, UK.
2008-2009 Inter-college Table Tennis Championship organized by Table Tennis Federation of India (TTFI).
2007-2008 Street drama act for general awareness of the heart disease. Organized by Indian heart foundation.
2007 Pharmaceutical industrial training at Process Development Lab, Ranbaxy Laboratories LTD, India. Handling of UV, IR, HPLC and flame photometric analysis for active pharmaceutical compounds.
Invited talk presentations
06/2017 Dutch Neuroscience 2017. “Seizures and disturbed brain extracellular potassium dynamics in MLC”
10/2015 15 Years Center for Childhood White Matter Disorders. “White matter edema; defects in ion and water homeostasis”
10/2015 GliaNED meeting 2015. “Impaired ion-water homeostasis causing epilepsy in leukodytrophy mouse models”
09/2015 15th Anniversary of childhood white matter disorder group. “White matter edema, disease and mechanism”
02/2015 FameLab Nijemgan, the Netherlands. “Brain Water Management system; insulation of brain electrical wires and beyond”
11/2014 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschouten, The Netherlands). “Astro-Dam” brain ion-water management system.
05/2014 Dutch Endo-Neuro-Psycho Meeting (Lunteren, The Netherlands). Role of astrocytes in Ion water homeostasis in the developing brain.
04/2014 International Astrocyte School (Bertinoro, Italy). Role of MLC1 protein in brain ion-water homeostasis.
04/2012 Dutch Glia meeting (Netherlands Institute of Neurosciences, Amsterdam, The Netherlands). Role of astrocytic MLC1 in myelinating brain.
12/2011 Childhood white matter disease group (VU-Medical Center, Amsterdam, The Netherlands). nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons.
Meetings/Symposia presentations
03/2017 Myelin meeting 2017 (Kassel, Germany) Dubey M, Brouwers E, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min. Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC. Poster
10/2016 Amsterdam Neuroscience 2016 annual meeting. Dubey M, Brouwers E, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min. Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC. Poster
03/2015 Gordon Research Conferences and Seminar (California, USA). Dubey M, Bugiani M, Eelke Browers, HD Mansvelder, Rogier Min and Marjo van der Knaap. Impaired ion-water homeostasis causing epilepsy in leukodytrophy mouse models. Poster
02/2015 Myelin meeting (Kassel, Germany). Dubey M, Bugiani M, Eelke Browers, HD Mansvelder, Rogier Min and Marjo van der Knaap. A mouse model of Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
02/2014 Amsterdam Kinder symposium (Amsterdam, The Netherlands). Dubey M, Bugiani M, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
11/2013 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschoten, The Netherlands). Dubey M, Bugiani M and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
07/2013 XI European meeting on Glial Cells in Health and Disease (Berlin, Germany). Dubey M, Bugiani M, HD Mansvelder and Marjo van der Knaap. Mouse model for Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
04/2013 Annual Neuroscience Campus Amsterdam meeting (Amsterdam, The Netherlands). Dubey M, Bugiani M, Polder E, Postma N, HD Mansvelder and Marjo van der Knaap. Mouse model for Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
02/2013 Amsterdam Kinder symposium (Amsterdam, The Netherlands). Dubey M, Bugiani, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
11/2012 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschoten, The Netherlands). Dubey M, Bugiani M and Marjo van der Knaap. Role of astrocytic MLC1 in brain ion water homeostasis. Poster
04/2012 Annual Neuroscience Campus Amsterdam meeting (Amsterdam, The Netherlands). Dubey M, Bugiani M, Polder E, Postma N, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
09/2010 OXION 2010-meeting. OXION: Ion Channels and Disease Initiative by Universities of Oxford, Cambridge, London and MRC Harwell (Oxford, The United Kingdom). Dubey M, Sazbo A and Kari Lamsa. nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons. Poster
Netherlands Institute for Neuroscience,
Royal Academy of Arts and Sciences,
Meibergdreef 47,
1105 BA Amsterdam,
The Netherlands
Date & place of Birth September 1985 (New Delhi, INDIA)
Education and Experience
2022-present: - ZonMw Dementia research fellow at Netherlands Institute for Neuroscience.
2017-2022:- Postdoc researcher at the Axonal Signalling group, under the supervision of Prof. Dr. Maarten Kole. Netherlands Institute for Neuroscience. The Netherlands
2018-2020:- Honorarium editor of Amsterdam Science Magazine, Science Park, Amsterdam
2011-2017: - PhD Neuroscience, Department of Child Neurology, VUmc & Department of Integrative Neurophysiology, CNCR, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands.
Supervisors: Prof. Dr. Marjo van der Knaap and Prof. Dr. Huib Mansvelder.
2009-2010: - Masters of Science in Pharmacology, University of Oxford, UK.
Grade: - Distinction in oral presentation, extended essay and qualifying exam.
Dissertation title: nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons.
Supervisor: Prof. Dr. Karri Lamsa.
2005-2009: - Bachelor of Pharmacy, Guru Gobind Singh IP Univ, New Delhi, India.
Registered Pharmacist, Indian Pharmacy Council, New Delhi, India.
Grade: - 81.54%. First with distinction.
Project title: Characterization of anti-epileptic drugs in epileptic mice model.
Supervisor: Prof. Dr. Uma Tekur, Department of Pharmacology, Maulana Azad Medical College. New Delhi, India.
Proven skills and strengths
- Single cell (Neurons/Interneurons/astrocytes) whole cell patch-clamp recordings
- Field and network recordings from acute brain slices
- Ion-sensitive micro-electrode recordings
- In-vivo radio-telemetry recordings
- Primary astrocyte and DRG myelination cultures
- In-vivo and In-vitro optogenetics
- Immunohistochemisty and Immunocytochemistry
- Micro-surgeries and implantation of brain probes and toxin injections.
Awards
2016 Mahatma Gandhi Pravasi Samman (civilian award), Global India Summit 2016 from NRI society at the House of Lords, London, UK.
2016 ICEN Travel award to FENS meeting- Copenhagen, Denmark.
2015 Best presentation award, Annual Neuroscience Campus Amsterdam, The Netherlands.
2015 NIH-Chair travel funds for Gordon Conference and Seminars, California, USA.
2015 FameLab heat Nijmegen, British Council Netherlands.
2014 Outstanding Scientific Contribution award, International Astrocyte School, Italy.
2014 Best presentation award, Amsterdam Children Symposium, Amsterdam, The Netherlands.
2013 Best presentation award, Annual Neuroscience Campus Amsterdam, The Netherlands.
2009 Oxford-Cambridge Indian Society nomination for Masters study at Oxford University.
2009 GATE 2009 (Graduate Aptitude Test in Engineering); exam-based scholarship conducted by 7 Indian Institute of Technology, MHRD, Govt. of India.
2002 Outstanding performance at National Science Exhibition, National Center for Education and Training (NCERT), Govt. of India.
2001 Outstanding performance at State Science Exhibition, Directorate of Education, Govt. of Delhi.
Teaching experience
2015 EEG radio-telemtry, FENS summer school (The Netherlands).
2014 Supervision of a neuroscience master student (University of Amsterdam, The Netherlands)
2013 Supervision of a neuroscience master student (University of Amsterdam, The Netherlands)
2012 Practical training for electrophysiology in Neuroscience course (Master program in neuroscience, VU university, Amsterdam, The Netherlands)
2010 Practical and surgical training at Medical Science Training Center (Bachelor program in Medicine & Physiology, University of Oxford, The United Kingdom
2009 Class room teaching of physics and physiology for International Baccalaureate students (St Hildas College, SAES, Oxford, The United Kingdom)
Publication
Mice with Megalencephalic Leukoencephalopathy with Cysts: A developmental angle.
Dubey M*, Bugiani M*, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weeing JR, M Heine V, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS. (Annals of Neurology; 2015). Image from the study selected for front page of the journal. (*Equal contribution)
Megalencephalic Leukoencephalopathy with Cysts; the Glialcam-null mouse model. Bugiani M*, Dubey M*, M. Breur, N.L. Postma, M.P. Dekker, T. ter Braak, U. Boschert, T.E.M. Abbink, H.D. Mansvelder, R. Min, J.R.T. van Weering, M.S. van der Knaap (Annals of Clinical and Translational Neurology; 2017) (*Equal contribution)
Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC.
Dubey M*, Brouwers E*, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min (Annals of Neurology; 2018) (*Equal contribution)
Seizures and cognitive deficits in STXBP1-encephalopathy are explained by impaired protein stability, haploinsufficiency and excitation-inhibition imbalance, especially in neocortex. Kovačević J*, Maroteaux G*, Schut D*, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse L. N, Sullivan P, Schoch-McGovern S, Toonen R F., Stiedl O and Verhage Matthijs. (Brain; 2018) (*Equal contribution)
Continue Education
2014 4th International Astrocyte School (Bertinoro, Italy)
2014 “Write it Right” from NWO, The Netherlands.
2011-14 Graduate School Neurosciences Amsterdam (modules attended)
2011 Handling of experimental animals (Dutch certificate article 9)
2009 Home office, UK personal license module 1-4 for rat, mouse and guniea pig.
Additional activities and memberships
2015- 2016 Honorarium editor of Amsterdam Science Magazine, Science Park, Amsterdam
2011- Present Member of the Federation of European Neuroscience Society (FENS).
2011- Present Member of the Dutch Neuro-federation.
2010- Present Member of the Oxford-Cambridge Indian Society, New Delhi, India
2009- Present Lifetime member of the Indian Pharmacy Graduate Association(IPGA), India.
2012- 2014 Member of the organizing committee of the annual meeting for PhD students of the Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience (ONWAR).
2013- 2014 Founder member and President of the VU-University Indian Society,Amsterdam, The Netherlands.
2011-2014 Member of the organizing committee of the monthly meetings for PhD students of the Center for Neurogenomics & Cognitive Research (CNCR), The Netherlands.
2009-2010 Worked as ancient book coder at Oxford University Bodleian Library, University of Oxford, The United Kingdom.
2009-2010 Member of the Oxford Indian Society, University of Oxford, UK.
2008-2009 Inter-college Table Tennis Championship organized by Table Tennis Federation of India (TTFI).
2007-2008 Street drama act for general awareness of the heart disease. Organized by Indian heart foundation.
2007 Pharmaceutical industrial training at Process Development Lab, Ranbaxy Laboratories LTD, India. Handling of UV, IR, HPLC and flame photometric analysis for active pharmaceutical compounds.
Invited talk presentations
06/2017 Dutch Neuroscience 2017. “Seizures and disturbed brain extracellular potassium dynamics in MLC”
10/2015 15 Years Center for Childhood White Matter Disorders. “White matter edema; defects in ion and water homeostasis”
10/2015 GliaNED meeting 2015. “Impaired ion-water homeostasis causing epilepsy in leukodytrophy mouse models”
09/2015 15th Anniversary of childhood white matter disorder group. “White matter edema, disease and mechanism”
02/2015 FameLab Nijemgan, the Netherlands. “Brain Water Management system; insulation of brain electrical wires and beyond”
11/2014 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschouten, The Netherlands). “Astro-Dam” brain ion-water management system.
05/2014 Dutch Endo-Neuro-Psycho Meeting (Lunteren, The Netherlands). Role of astrocytes in Ion water homeostasis in the developing brain.
04/2014 International Astrocyte School (Bertinoro, Italy). Role of MLC1 protein in brain ion-water homeostasis.
04/2012 Dutch Glia meeting (Netherlands Institute of Neurosciences, Amsterdam, The Netherlands). Role of astrocytic MLC1 in myelinating brain.
12/2011 Childhood white matter disease group (VU-Medical Center, Amsterdam, The Netherlands). nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons.
Meetings/Symposia presentations
03/2017 Myelin meeting 2017 (Kassel, Germany) Dubey M, Brouwers E, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min. Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC. Poster
10/2016 Amsterdam Neuroscience 2016 annual meeting. Dubey M, Brouwers E, Eline M.C. Hamilton, Oliver Stiedl, Marianna Bugiani, Henner Koch, Ursula Boschert, Robert C. Wykes, Huibert D. Mansvelder, Marjo S. van der Knaap and Rogier Min. Seizures and disturbed brain potassium dynamics in the leukodystrophy MLC. Poster
03/2015 Gordon Research Conferences and Seminar (California, USA). Dubey M, Bugiani M, Eelke Browers, HD Mansvelder, Rogier Min and Marjo van der Knaap. Impaired ion-water homeostasis causing epilepsy in leukodytrophy mouse models. Poster
02/2015 Myelin meeting (Kassel, Germany). Dubey M, Bugiani M, Eelke Browers, HD Mansvelder, Rogier Min and Marjo van der Knaap. A mouse model of Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
02/2014 Amsterdam Kinder symposium (Amsterdam, The Netherlands). Dubey M, Bugiani M, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
11/2013 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschoten, The Netherlands). Dubey M, Bugiani M and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
07/2013 XI European meeting on Glial Cells in Health and Disease (Berlin, Germany). Dubey M, Bugiani M, HD Mansvelder and Marjo van der Knaap. Mouse model for Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
04/2013 Annual Neuroscience Campus Amsterdam meeting (Amsterdam, The Netherlands). Dubey M, Bugiani M, Polder E, Postma N, HD Mansvelder and Marjo van der Knaap. Mouse model for Megalencephalic Leukoencephalopathy with subcortical cysts. Poster
02/2013 Amsterdam Kinder symposium (Amsterdam, The Netherlands). Dubey M, Bugiani, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
11/2012 Graduate School Neuroscience Amsterdam and Rudolf Magnus Graduate School of Neuroscience annual meeting (Woudschoten, The Netherlands). Dubey M, Bugiani M and Marjo van der Knaap. Role of astrocytic MLC1 in brain ion water homeostasis. Poster
04/2012 Annual Neuroscience Campus Amsterdam meeting (Amsterdam, The Netherlands). Dubey M, Bugiani M, Polder E, Postma N, HD Mansvelder and Marjo van der Knaap. Astrocytic MLC1 involved in brain water homeostasis and myelin integrity. Poster
09/2010 OXION 2010-meeting. OXION: Ion Channels and Disease Initiative by Universities of Oxford, Cambridge, London and MRC Harwell (Oxford, The United Kingdom). Dubey M, Sazbo A and Kari Lamsa. nAChR mediated synaptic plasticity modulation in anatomically identified hippocampal inhibitory interneurons. Poster